| Middlesbrough to Sestu | 1,159.73 mi (1,866.40 km) |
| Middlesbrough to Settimo Torinese | 764.49 mi (1,230.32 km) |
| Middlesbrough to Seveso | 767.87 mi (1,235.77 km) |
| Middlesbrough to Sezze | 1,114.76 mi (1,794.04 km) |
| Middlesbrough to Siano | 1,200.20 mi (1,931.54 km) |
| Middlesbrough to Siena | 961.43 mi (1,547.27 km) |
| Middlesbrough to Signa | 928.03 mi (1,493.52 km) |
| Middlesbrough to Silea | 857.11 mi (1,379.38 km) |
| Middlesbrough to Silvi Paese | 1,082.97 mi (1,742.88 km) |
| Middlesbrough to Sinalunga | 978.07 mi (1,574.05 km) |
| Middlesbrough to Siniscola | 1,090.53 mi (1,755.04 km) |
| Middlesbrough to Sinnai | 1,161.67 mi (1,869.53 km) |
| Middlesbrough to Siracusa | 1,439.88 mi (2,317.26 km) |
| Middlesbrough to Solaro | 768.13 mi (1,236.18 km) |
| Middlesbrough to Soliera | 868.06 mi (1,397.00 km) |
