| Mission Viejo to Ede | 5,601.78 mi (9,015.19 km) |
| Mission Viejo to Eemnes | 5,579.52 mi (8,979.37 km) |
| Mission Viejo to Eerbeek | 5,610.90 mi (9,029.87 km) |
| Mission Viejo to Eersel | 5,625.48 mi (9,053.34 km) |
| Mission Viejo to Eijsden | 5,665.52 mi (9,117.77 km) |
| Mission Viejo to Eindhoven | 5,626.48 mi (9,054.94 km) |
| Mission Viejo to Elburg | 5,587.61 mi (8,992.39 km) |
| Mission Viejo to Emmeloord | 5,571.93 mi (8,967.16 km) |
| Mission Viejo to Emmen | 5,601.92 mi (9,015.42 km) |
| Mission Viejo to Enkhuizen | 5,559.07 mi (8,946.46 km) |
| Mission Viejo to Enschede | 5,630.11 mi (9,060.78 km) |
| Mission Viejo to Epe | 5,596.47 mi (9,006.65 km) |
| Mission Viejo to Ermelo | 5,588.03 mi (8,993.07 km) |
| Mission Viejo to Etten-Leur | 5,594.05 mi (9,002.76 km) |
| Mission Viejo to Franeker | 5,541.55 mi (8,918.26 km) |
