| Mytilini to Sangeorz-Bai | 579.05 mi (931.90 km) |
| Mytilini to Sannicolau Mare | 567.72 mi (913.65 km) |
| Mytilini to Santana | 562.40 mi (905.10 km) |
| Mytilini to Satu Mare | 627.67 mi (1,010.14 km) |
| Mytilini to Scobinti | 572.64 mi (921.58 km) |
| Mytilini to Scornicesti | 391.68 mi (630.34 km) |
| Mytilini to Sebes | 497.57 mi (800.77 km) |
| Mytilini to Seini | 619.40 mi (996.83 km) |
| Mytilini to Sfantu-Gheorghe | 468.93 mi (754.66 km) |
| Mytilini to Sibiu | 478.25 mi (769.68 km) |
| Mytilini to Sighetu Marmatiei | 624.26 mi (1,004.64 km) |
| Mytilini to Sighisoara | 499.75 mi (804.27 km) |
| Mytilini to Simeria | 499.92 mi (804.54 km) |
| Mytilini to Sinaia | 434.83 mi (699.80 km) |
| Mytilini to Slatina | 385.05 mi (619.68 km) |
