| Natchez to Enterprise (Nevada) | 1,399.75 mi (2,252.68 km) |
| Natchez to Enumclaw (Washington) | 1,940.57 mi (3,123.05 km) |
| Natchez to Ephrata (Pennsylvania) | 1,037.35 mi (1,669.45 km) |
| Natchez to Erie (Colorado) | 962.53 mi (1,549.04 km) |
| Natchez to Erie (Pennsylvania) | 960.04 mi (1,545.04 km) |
| Natchez to Erlanger (Kentucky) | 642.45 mi (1,033.92 km) |
| Natchez to Escanaba (Michigan) | 1,008.01 mi (1,622.24 km) |
| Natchez to Escondido (California) | 1,499.72 mi (2,413.57 km) |
| Natchez to Española (New Mexico) | 896.64 mi (1,443.01 km) |
| Natchez to Essex (Maryland) | 995.50 mi (1,602.11 km) |
| Natchez to Essex Junction (Vermont) | 1,332.03 mi (2,143.70 km) |
| Natchez to Estelle (Louisiana) | 140.02 mi (225.33 km) |
| Natchez to Estero (Florida) | 678.53 mi (1,091.98 km) |
| Natchez to Euclid (Ohio) | 882.84 mi (1,420.80 km) |
| Natchez to Eufaula (Alabama) | 367.31 mi (591.13 km) |
