| Neu Isenburg to Oria | 788.72 mi (1,269.32 km) |
| Neu Isenburg to Oristano | 700.92 mi (1,128.02 km) |
| Neu Isenburg to Orta Nova | 690.26 mi (1,110.86 km) |
| Neu Isenburg to Orte | 553.00 mi (889.96 km) |
| Neu Isenburg to Ortona | 597.36 mi (961.36 km) |
| Neu Isenburg to Orvieto | 531.86 mi (855.95 km) |
| Neu Isenburg to Orzinuovi | 326.34 mi (525.20 km) |
| Neu Isenburg to Osimo | 506.80 mi (815.61 km) |
| Neu Isenburg to Ospitaletto | 317.01 mi (510.18 km) |
| Neu Isenburg to Ostuni | 773.50 mi (1,244.83 km) |
| Neu Isenburg to Ottaviano | 694.09 mi (1,117.03 km) |
| Neu Isenburg to Ovada | 373.86 mi (601.67 km) |
| Neu Isenburg to Ozieri | 654.14 mi (1,052.74 km) |
| Neu Isenburg to Paceco | 855.09 mi (1,376.13 km) |
| Neu Isenburg to Pachino | 974.78 mi (1,568.76 km) |
