| Neu Isenburg to Spilamberto | 396.27 mi (637.74 km) |
| Neu Isenburg to Spilimbergo | 332.65 mi (535.35 km) |
| Neu Isenburg to Spinea | 353.40 mi (568.73 km) |
| Neu Isenburg to Spoleto | 538.32 mi (866.34 km) |
| Neu Isenburg to Spoltore | 585.21 mi (941.81 km) |
| Neu Isenburg to Spresiano | 337.44 mi (543.06 km) |
| Neu Isenburg to Squinzano | 803.87 mi (1,293.70 km) |
| Neu Isenburg to Statte | 773.42 mi (1,244.71 km) |
| Neu Isenburg to Stezzano | 307.14 mi (494.30 km) |
| Neu Isenburg to Strada | 463.54 mi (746.00 km) |
| Neu Isenburg to Stradella | 344.30 mi (554.10 km) |
| Neu Isenburg to Striano | 697.96 mi (1,123.26 km) |
| Neu Isenburg to Subiaco | 598.99 mi (963.99 km) |
| Neu Isenburg to Sulmona | 606.66 mi (976.32 km) |
| Neu Isenburg to Surbo | 808.11 mi (1,300.52 km) |
