| New Smyrna Beach to Sacile | 4,961.94 mi (7,985.47 km) |
| New Smyrna Beach to Sala Consilina | 5,265.75 mi (8,474.41 km) |
| New Smyrna Beach to Salemi | 5,209.40 mi (8,383.72 km) |
| New Smyrna Beach to Salerno | 5,217.61 mi (8,396.93 km) |
| New Smyrna Beach to Salo | 4,884.30 mi (7,860.53 km) |
| New Smyrna Beach to Salsomaggiore Terme | 4,879.75 mi (7,853.19 km) |
| New Smyrna Beach to Saluzzo | 4,770.21 mi (7,676.90 km) |
| New Smyrna Beach to Salzano | 4,956.76 mi (7,977.13 km) |
| New Smyrna Beach to Samarate | 4,805.23 mi (7,733.28 km) |
| New Smyrna Beach to San Benedetto del Tronto | 5,109.38 mi (8,222.75 km) |
| New Smyrna Beach to San Biagio di Callalta | 4,964.34 mi (7,989.34 km) |
| New Smyrna Beach to San Bonifacio | 4,923.15 mi (7,923.04 km) |
| New Smyrna Beach to San Casciano in Val di Pesa | 4,965.62 mi (7,991.40 km) |
| New Smyrna Beach to San Cataldo | 5,277.68 mi (8,493.61 km) |
| New Smyrna Beach to San Cesareo | 5,092.02 mi (8,194.81 km) |
