| New Smyrna Beach to Sestu | 4,984.64 mi (8,022.00 km) |
| New Smyrna Beach to Settimo Torinese | 4,770.99 mi (7,678.17 km) |
| New Smyrna Beach to Seveso | 4,820.52 mi (7,757.88 km) |
| New Smyrna Beach to Sezze | 5,113.68 mi (8,229.67 km) |
| New Smyrna Beach to Siano | 5,210.84 mi (8,386.04 km) |
| New Smyrna Beach to Siena | 4,981.57 mi (8,017.05 km) |
| New Smyrna Beach to Signa | 4,958.26 mi (7,979.54 km) |
| New Smyrna Beach to Silea | 4,961.45 mi (7,984.69 km) |
| New Smyrna Beach to Silvi Paese | 5,131.82 mi (8,258.86 km) |
| New Smyrna Beach to Sinalunga | 5,002.91 mi (8,051.40 km) |
| New Smyrna Beach to Siniscola | 4,979.30 mi (8,013.41 km) |
| New Smyrna Beach to Sinnai | 4,990.02 mi (8,030.66 km) |
| New Smyrna Beach to Siracusa | 5,354.59 mi (8,617.39 km) |
| New Smyrna Beach to Solaro | 4,818.83 mi (7,755.15 km) |
| New Smyrna Beach to Soliera | 4,924.62 mi (7,925.41 km) |
