| New Smyrna Beach to Spello | 5,052.59 mi (8,131.35 km) |
| New Smyrna Beach to Spilamberto | 4,934.27 mi (7,940.94 km) |
| New Smyrna Beach to Spilimbergo | 4,974.47 mi (8,005.64 km) |
| New Smyrna Beach to Spinea | 4,959.81 mi (7,982.04 km) |
| New Smyrna Beach to Spoleto | 5,059.80 mi (8,142.96 km) |
| New Smyrna Beach to Spoltore | 5,135.68 mi (8,265.09 km) |
| New Smyrna Beach to Spresiano | 4,955.88 mi (7,975.72 km) |
| New Smyrna Beach to Squinzano | 5,379.27 mi (8,657.10 km) |
| New Smyrna Beach to Statte | 5,335.44 mi (8,586.57 km) |
| New Smyrna Beach to Stezzano | 4,843.51 mi (7,794.88 km) |
| New Smyrna Beach to Strada | 4,973.65 mi (8,004.31 km) |
| New Smyrna Beach to Stradella | 4,842.00 mi (7,792.45 km) |
| New Smyrna Beach to Striano | 5,204.41 mi (8,375.69 km) |
| New Smyrna Beach to Subiaco | 5,102.67 mi (8,211.96 km) |
| New Smyrna Beach to Sulmona | 5,137.78 mi (8,268.46 km) |
