| Newcastle under Lyme to Sacile | 818.31 mi (1,316.94 km) |
| Newcastle under Lyme to Sala Consilina | 1,207.07 mi (1,942.59 km) |
| Newcastle under Lyme to Salemi | 1,272.42 mi (2,047.77 km) |
| Newcastle under Lyme to Salerno | 1,164.80 mi (1,874.56 km) |
| Newcastle under Lyme to Salo | 767.84 mi (1,235.72 km) |
| Newcastle under Lyme to Salsomaggiore Terme | 790.38 mi (1,272.00 km) |
| Newcastle under Lyme to Saluzzo | 726.31 mi (1,168.88 km) |
| Newcastle under Lyme to Salzano | 825.14 mi (1,327.93 km) |
| Newcastle under Lyme to Samarate | 710.52 mi (1,143.47 km) |
| Newcastle under Lyme to San Benedetto del Tronto | 1,014.75 mi (1,633.09 km) |
| Newcastle under Lyme to San Biagio di Callalta | 827.14 mi (1,331.16 km) |
| Newcastle under Lyme to San Bonifacio | 802.99 mi (1,292.29 km) |
| Newcastle under Lyme to San Casciano in Val di Pesa | 890.11 mi (1,432.49 km) |
| Newcastle under Lyme to San Cataldo | 1,324.88 mi (2,132.19 km) |
| Newcastle under Lyme to San Cesareo | 1,040.77 mi (1,674.96 km) |
