| Newcastle under Lyme to Santa Venerina | 1,346.17 mi (2,166.46 km) |
| Newcastle under Lyme to Santeramo in Colle | 1,224.06 mi (1,969.94 km) |
| Newcastle under Lyme to Santo Stefano di Magra | 823.50 mi (1,325.29 km) |
| Newcastle under Lyme to Santo Stino di Livenza | 835.67 mi (1,344.88 km) |
| Newcastle under Lyme to Sarezzo | 754.27 mi (1,213.88 km) |
| Newcastle under Lyme to Sarno | 1,152.78 mi (1,855.22 km) |
| Newcastle under Lyme to Saronno | 717.99 mi (1,155.50 km) |
| Newcastle under Lyme to Sarzana | 827.53 mi (1,331.78 km) |
| Newcastle under Lyme to Sassari | 987.53 mi (1,589.27 km) |
| Newcastle under Lyme to Sasso Marconi | 852.75 mi (1,372.36 km) |
| Newcastle under Lyme to Sassuolo | 829.85 mi (1,335.51 km) |
| Newcastle under Lyme to Sava | 1,272.22 mi (2,047.45 km) |
| Newcastle under Lyme to Saviano | 1,144.12 mi (1,841.28 km) |
| Newcastle under Lyme to Savigliano | 729.96 mi (1,174.76 km) |
| Newcastle under Lyme to Savignano sul Panaro | 841.39 mi (1,354.09 km) |
