| Newcastle under Lyme to Selargius | 1,092.82 mi (1,758.72 km) |
| Newcastle under Lyme to Selvazzano Dentro | 820.86 mi (1,321.04 km) |
| Newcastle under Lyme to Senago | 723.24 mi (1,163.94 km) |
| Newcastle under Lyme to Senigallia | 953.15 mi (1,533.95 km) |
| Newcastle under Lyme to Seravezza | 842.06 mi (1,355.16 km) |
| Newcastle under Lyme to Seregno | 721.87 mi (1,161.73 km) |
| Newcastle under Lyme to Seriate | 736.71 mi (1,185.62 km) |
| Newcastle under Lyme to Sermoneta | 1,061.20 mi (1,707.83 km) |
| Newcastle under Lyme to Serramanna | 1,076.75 mi (1,732.86 km) |
| Newcastle under Lyme to Serravalle Pistoiese | 866.00 mi (1,393.70 km) |
| Newcastle under Lyme to Sessa Aurunca | 1,108.29 mi (1,783.61 km) |
| Newcastle under Lyme to Sesto Calende | 699.69 mi (1,126.04 km) |
| Newcastle under Lyme to Sesto Fiorentino | 881.09 mi (1,417.97 km) |
| Newcastle under Lyme to Sesto San Giovanni | 729.01 mi (1,173.24 km) |
| Newcastle under Lyme to Sestri Levante | 801.71 mi (1,290.23 km) |
