| Newcastle under Lyme to Sestu | 1,088.37 mi (1,751.57 km) |
| Newcastle under Lyme to Settimo Torinese | 706.40 mi (1,136.84 km) |
| Newcastle under Lyme to Seveso | 720.23 mi (1,159.09 km) |
| Newcastle under Lyme to Sezze | 1,066.54 mi (1,716.44 km) |
| Newcastle under Lyme to Siano | 1,156.03 mi (1,860.45 km) |
| Newcastle under Lyme to Siena | 912.97 mi (1,469.29 km) |
| Newcastle under Lyme to Signa | 880.62 mi (1,417.22 km) |
| Newcastle under Lyme to Silea | 825.66 mi (1,328.78 km) |
| Newcastle under Lyme to Silvi Paese | 1,043.40 mi (1,679.19 km) |
| Newcastle under Lyme to Sinalunga | 931.02 mi (1,498.33 km) |
| Newcastle under Lyme to Siniscola | 1,024.90 mi (1,649.41 km) |
| Newcastle under Lyme to Sinnai | 1,090.77 mi (1,755.43 km) |
| Newcastle under Lyme to Siracusa | 1,386.59 mi (2,231.50 km) |
| Newcastle under Lyme to Solaro | 720.02 mi (1,158.76 km) |
| Newcastle under Lyme to Soliera | 824.62 mi (1,327.09 km) |
