| Newcastle under Lyme to Spello | 973.06 mi (1,565.99 km) |
| Newcastle under Lyme to Spilamberto | 838.25 mi (1,349.03 km) |
| Newcastle under Lyme to Spilimbergo | 824.84 mi (1,327.45 km) |
| Newcastle under Lyme to Spinea | 828.60 mi (1,333.50 km) |
| Newcastle under Lyme to Spoleto | 985.93 mi (1,586.71 km) |
| Newcastle under Lyme to Spoltore | 1,049.16 mi (1,688.47 km) |
| Newcastle under Lyme to Spresiano | 817.95 mi (1,316.37 km) |
| Newcastle under Lyme to Squinzano | 1,286.99 mi (2,071.21 km) |
| Newcastle under Lyme to Statte | 1,251.01 mi (2,013.31 km) |
| Newcastle under Lyme to Stezzano | 736.34 mi (1,185.03 km) |
| Newcastle under Lyme to Strada | 898.17 mi (1,445.47 km) |
| Newcastle under Lyme to Stradella | 754.90 mi (1,214.89 km) |
| Newcastle under Lyme to Striano | 1,151.19 mi (1,852.67 km) |
| Newcastle under Lyme to Subiaco | 1,043.70 mi (1,679.68 km) |
| Newcastle under Lyme to Sulmona | 1,063.82 mi (1,712.05 km) |
