| Newcastle under Lyme to Sesimbra | 1,058.47 mi (1,703.44 km) |
| Newcastle under Lyme to Setubal | 1,050.09 mi (1,689.95 km) |
| Newcastle under Lyme to Sever do Vouga | 895.67 mi (1,441.44 km) |
| Newcastle under Lyme to Silves | 1,133.46 mi (1,824.13 km) |
| Newcastle under Lyme to Sines | 1,087.68 mi (1,750.44 km) |
| Newcastle under Lyme to Sintra | 1,039.27 mi (1,672.54 km) |
| Newcastle under Lyme to Sobrado de Paiva | 874.32 mi (1,407.07 km) |
| Newcastle under Lyme to Sobral de Monte Agraco | 1,021.14 mi (1,643.37 km) |
| Newcastle under Lyme to Soure | 944.92 mi (1,520.70 km) |
| Newcastle under Lyme to Tabua | 915.55 mi (1,473.43 km) |
| Newcastle under Lyme to Tavira | 1,128.80 mi (1,816.63 km) |
| Newcastle under Lyme to Tomar | 971.65 mi (1,563.71 km) |
| Newcastle under Lyme to Tondela | 905.90 mi (1,457.91 km) |
| Newcastle under Lyme to Torre de Moncorvo | 847.53 mi (1,363.96 km) |
| Newcastle under Lyme to Torres Novas | 982.18 mi (1,580.67 km) |
