| Newcastle under Lyme to Sesena | 894.49 mi (1,439.54 km) |
| Newcastle under Lyme to Sestao | 671.16 mi (1,080.13 km) |
| Newcastle under Lyme to Sevilla | 1,104.60 mi (1,777.68 km) |
| Newcastle under Lyme to Sevilla La Nueva | 879.04 mi (1,414.67 km) |
| Newcastle under Lyme to Silla | 946.98 mi (1,524.02 km) |
| Newcastle under Lyme to Silleda | 764.22 mi (1,229.90 km) |
| Newcastle under Lyme to Sitges | 835.15 mi (1,344.05 km) |
| Newcastle under Lyme to Socuellamos | 948.17 mi (1,525.94 km) |
| Newcastle under Lyme to Soller | 944.17 mi (1,519.49 km) |
| Newcastle under Lyme to Solsona | 780.71 mi (1,256.43 km) |
| Newcastle under Lyme to Son Servera | 962.09 mi (1,548.33 km) |
| Newcastle under Lyme to Sonseca | 923.28 mi (1,485.88 km) |
| Newcastle under Lyme to Sopelana | 666.22 mi (1,072.18 km) |
| Newcastle under Lyme to Soria | 776.98 mi (1,250.43 km) |
| Newcastle under Lyme to Suances | 666.98 mi (1,073.41 km) |
