| Newcastle under Lyme to Nottingham | 45.01 mi (72.44 km) |
| Newcastle under Lyme to Nuneaton | 46.32 mi (74.54 km) |
| Newcastle under Lyme to Oadby | 55.90 mi (89.96 km) |
| Newcastle under Lyme to Oakengates | 23.73 mi (38.19 km) |
| Newcastle under Lyme to Oakham | 66.66 mi (107.28 km) |
| Newcastle under Lyme to Oldbury | 36.06 mi (58.03 km) |
| Newcastle under Lyme to Oldham | 37.14 mi (59.78 km) |
| Newcastle under Lyme to Ollerton | 51.77 mi (83.32 km) |
| Newcastle under Lyme to Olton | 43.36 mi (69.79 km) |
| Newcastle under Lyme to Omagh | 233.54 mi (375.84 km) |
| Newcastle under Lyme to Ormesby | 114.54 mi (184.34 km) |
| Newcastle under Lyme to Ormskirk | 47.06 mi (75.74 km) |
| Newcastle under Lyme to Orpington | 149.98 mi (241.37 km) |
| Newcastle under Lyme to Ossett | 53.40 mi (85.93 km) |
| Newcastle under Lyme to Oswaldtwistle | 51.04 mi (82.14 km) |
