| Newcastle under Lyme to Saint Ives | 238.48 mi (383.79 km) |
| Newcastle under Lyme to Saint Neots | 98.33 mi (158.25 km) |
| Newcastle under Lyme to Sale | 28.81 mi (46.36 km) |
| Newcastle under Lyme to Salford | 32.73 mi (52.67 km) |
| Newcastle under Lyme to Salisbury | 135.39 mi (217.88 km) |
| Newcastle under Lyme to Saltash | 198.88 mi (320.06 km) |
| Newcastle under Lyme to Saltcoats | 208.62 mi (335.73 km) |
| Newcastle under Lyme to Sandbach | 10.98 mi (17.67 km) |
| Newcastle under Lyme to Sanderstead | 147.17 mi (236.85 km) |
| Newcastle under Lyme to Sandhurst | 129.78 mi (208.86 km) |
| Newcastle under Lyme to Sandiacre | 39.45 mi (63.49 km) |
| Newcastle under Lyme to Sandown | 169.10 mi (272.14 km) |
| Newcastle under Lyme to Sandridge | 117.48 mi (189.07 km) |
| Newcastle under Lyme to Sandy | 101.34 mi (163.08 km) |
| Newcastle under Lyme to Scarborough | 115.10 mi (185.24 km) |
