| Newcastle under Lyme to Scartho | 95.48 mi (153.67 km) |
| Newcastle under Lyme to Scunthorpe | 76.12 mi (122.51 km) |
| Newcastle under Lyme to Seacombe | 43.08 mi (69.33 km) |
| Newcastle under Lyme to Seacroft | 64.36 mi (103.57 km) |
| Newcastle under Lyme to Seaford | 183.90 mi (295.95 km) |
| Newcastle under Lyme to Seaham | 131.44 mi (211.53 km) |
| Newcastle under Lyme to Sedgley | 32.83 mi (52.83 km) |
| Newcastle under Lyme to Selby | 71.49 mi (115.05 km) |
| Newcastle under Lyme to Selsey | 168.78 mi (271.63 km) |
| Newcastle under Lyme to Selston | 38.76 mi (62.38 km) |
| Newcastle under Lyme to Sevenoaks | 157.53 mi (253.52 km) |
| Newcastle under Lyme to Shanklin | 170.31 mi (274.09 km) |
| Newcastle under Lyme to Sheerness | 166.58 mi (268.08 km) |
| Newcastle under Lyme to Sheffield | 40.45 mi (65.10 km) |
| Newcastle under Lyme to Sheldon | 43.29 mi (69.67 km) |
