| Newcastle under Lyme to Shotley Bridge | 129.32 mi (208.12 km) |
| Newcastle under Lyme to Shrewsbury | 30.33 mi (48.81 km) |
| Newcastle under Lyme to Sidcup | 147.35 mi (237.14 km) |
| Newcastle under Lyme to Sidmouth | 166.73 mi (268.32 km) |
| Newcastle under Lyme to Sileby | 50.62 mi (81.47 km) |
| Newcastle under Lyme to Sittingbourne | 170.68 mi (274.69 km) |
| Newcastle under Lyme to Skegness | 107.09 mi (172.34 km) |
| Newcastle under Lyme to Skelmersdale | 43.59 mi (70.15 km) |
| Newcastle under Lyme to Skipton | 66.32 mi (106.73 km) |
| Newcastle under Lyme to Sleaford | 75.46 mi (121.44 km) |
| Newcastle under Lyme to Slough | 124.84 mi (200.90 km) |
| Newcastle under Lyme to Small Heath | 40.96 mi (65.92 km) |
| Newcastle under Lyme to Smethwick | 37.38 mi (60.16 km) |
| Newcastle under Lyme to Snaresbrook | 136.58 mi (219.80 km) |
| Newcastle under Lyme to Snodland | 162.35 mi (261.28 km) |
