| Newcastle under Lyme to Southwick | 136.02 mi (218.90 km) |
| Newcastle under Lyme to Southwick | 172.50 mi (277.62 km) |
| Newcastle under Lyme to Sowerby Bridge | 50.05 mi (80.55 km) |
| Newcastle under Lyme to Spalding | 87.86 mi (141.40 km) |
| Newcastle under Lyme to Spennymoor | 119.56 mi (192.42 km) |
| Newcastle under Lyme to Spitalfields | 137.64 mi (221.50 km) |
| Newcastle under Lyme to Spondon | 34.98 mi (56.29 km) |
| Newcastle under Lyme to Stafford | 14.83 mi (23.86 km) |
| Newcastle under Lyme to Staines-upon-Thames | 130.95 mi (210.75 km) |
| Newcastle under Lyme to Stalybridge | 33.56 mi (54.00 km) |
| Newcastle under Lyme to Stamford | 76.81 mi (123.61 km) |
| Newcastle under Lyme to Standish | 43.63 mi (70.21 km) |
| Newcastle under Lyme to Stanford le Hope | 152.55 mi (245.50 km) |
| Newcastle under Lyme to Stanley | 57.65 mi (92.79 km) |
| Newcastle under Lyme to Stanmore | 125.68 mi (202.26 km) |
