| Newcastle under Lyme to Stannington | 39.09 mi (62.90 km) |
| Newcastle under Lyme to Stansted Mountfitchet | 127.84 mi (205.73 km) |
| Newcastle under Lyme to Stanwell | 130.57 mi (210.13 km) |
| Newcastle under Lyme to Stapleford | 40.09 mi (64.52 km) |
| Newcastle under Lyme to Staveley | 40.59 mi (65.32 km) |
| Newcastle under Lyme to Stepney | 138.52 mi (222.92 km) |
| Newcastle under Lyme to Stevenage | 114.66 mi (184.53 km) |
| Newcastle under Lyme to Stevenston | 208.57 mi (335.67 km) |
| Newcastle under Lyme to Stirling | 225.22 mi (362.46 km) |
| Newcastle under Lyme to Stockport | 27.65 mi (44.50 km) |
| Newcastle under Lyme to Stocksbridge | 41.73 mi (67.16 km) |
| Newcastle under Lyme to Stockton-on-Tees | 113.92 mi (183.33 km) |
| Newcastle under Lyme to Stoke Gifford | 104.10 mi (167.54 km) |
| Newcastle under Lyme to Stoke-on-Trent | 2.00 mi (3.21 km) |
| Newcastle under Lyme to Stone | 8.32 mi (13.39 km) |
