| Newcastle under Lyme to Stonehaven | 273.13 mi (439.57 km) |
| Newcastle under Lyme to Stourbridge | 38.38 mi (61.77 km) |
| Newcastle under Lyme to Stowmarket | 146.83 mi (236.31 km) |
| Newcastle under Lyme to Stranraer | 173.24 mi (278.81 km) |
| Newcastle under Lyme to Stratford | 138.35 mi (222.66 km) |
| Newcastle under Lyme to Stratford-upon-Avon | 60.61 mi (97.55 km) |
| Newcastle under Lyme to Stratton Saint Margaret | 100.40 mi (161.58 km) |
| Newcastle under Lyme to Streatham | 141.04 mi (226.99 km) |
| Newcastle under Lyme to Street | 132.19 mi (212.75 km) |
| Newcastle under Lyme to Streetly | 33.24 mi (53.50 km) |
| Newcastle under Lyme to Stretford | 30.29 mi (48.75 km) |
| Newcastle under Lyme to Strood | 160.06 mi (257.58 km) |
| Newcastle under Lyme to Stroud | 87.54 mi (140.88 km) |
| Newcastle under Lyme to Sudbury | 128.99 mi (207.59 km) |
| Newcastle under Lyme to Sudbury | 141.14 mi (227.14 km) |
