| Newcastle under Lyme to Tyldesley | 36.31 mi (58.43 km) |
| Newcastle under Lyme to Tynemouth | 142.40 mi (229.18 km) |
| Newcastle under Lyme to Uckfield | 172.30 mi (277.29 km) |
| Newcastle under Lyme to Ulverston | 89.00 mi (143.22 km) |
| Newcastle under Lyme to Upminster | 145.20 mi (233.68 km) |
| Newcastle under Lyme to Upton | 44.37 mi (71.40 km) |
| Newcastle under Lyme to Urmston | 30.85 mi (49.65 km) |
| Newcastle under Lyme to Usworth | 136.10 mi (219.04 km) |
| Newcastle under Lyme to Uttoxeter | 17.18 mi (27.65 km) |
| Newcastle under Lyme to Uxbridge | 125.68 mi (202.25 km) |
| Newcastle under Lyme to Verwood | 147.88 mi (237.98 km) |
| Newcastle under Lyme to Wakefield | 55.35 mi (89.07 km) |
| Newcastle under Lyme to Walkden | 36.14 mi (58.17 km) |
| Newcastle under Lyme to Wallasey | 43.20 mi (69.52 km) |
| Newcastle under Lyme to Wallingford | 108.10 mi (173.98 km) |
