| Newcastle under Lyme to Enumclaw (Washington) | 4,661.73 mi (7,502.33 km) |
| Newcastle under Lyme to Ephrata (Pennsylvania) | 3,456.56 mi (5,562.79 km) |
| Newcastle under Lyme to Erie (Colorado) | 4,538.57 mi (7,304.13 km) |
| Newcastle under Lyme to Erie (Pennsylvania) | 3,522.11 mi (5,668.29 km) |
| Newcastle under Lyme to Erlanger (Kentucky) | 3,841.65 mi (6,182.54 km) |
| Newcastle under Lyme to Escanaba (Michigan) | 3,622.60 mi (5,830.02 km) |
| Newcastle under Lyme to Escondido (California) | 5,320.31 mi (8,562.21 km) |
| Newcastle under Lyme to Española (New Mexico) | 4,789.73 mi (7,708.32 km) |
| Newcastle under Lyme to Essex (Maryland) | 3,507.18 mi (5,644.26 km) |
| Newcastle under Lyme to Essex Junction (Vermont) | 3,147.15 mi (5,064.85 km) |
| Newcastle under Lyme to Estelle (Louisiana) | 4,516.20 mi (7,268.12 km) |
| Newcastle under Lyme to Estero (Florida) | 4,357.01 mi (7,011.93 km) |
| Newcastle under Lyme to Euclid (Ohio) | 3,602.06 mi (5,796.95 km) |
| Newcastle under Lyme to Eufaula (Alabama) | 4,213.20 mi (6,780.50 km) |
| Newcastle under Lyme to Eugene (Oregon) | 4,872.61 mi (7,841.71 km) |
