| Newcastle under Lyme to Olympia Heights (Florida) | 4,333.46 mi (6,974.04 km) |
| Newcastle under Lyme to Omaha (Nebraska) | 4,161.06 mi (6,696.57 km) |
| Newcastle under Lyme to On Top of the World Designated Place (Florida) | 4,239.66 mi (6,823.07 km) |
| Newcastle under Lyme to Onalaska (Wisconsin) | 3,858.40 mi (6,209.49 km) |
| Newcastle under Lyme to Oneida (New York) | 3,307.41 mi (5,322.77 km) |
| Newcastle under Lyme to Oneonta (New York) | 3,311.06 mi (5,328.64 km) |
| Newcastle under Lyme to Ontario (California) | 5,285.73 mi (8,506.56 km) |
| Newcastle under Lyme to Ontario (Oregon) | 4,700.88 mi (7,565.33 km) |
| Newcastle under Lyme to Opa-locka (Florida) | 4,320.92 mi (6,953.85 km) |
| Newcastle under Lyme to Opelika (Alabama) | 4,184.42 mi (6,734.17 km) |
| Newcastle under Lyme to Opelousas (Louisiana) | 4,558.92 mi (7,336.88 km) |
| Newcastle under Lyme to Orange (California) | 5,306.12 mi (8,539.38 km) |
| Newcastle under Lyme to Orange (Texas) | 4,645.57 mi (7,476.33 km) |
| Newcastle under Lyme to Orange City (Florida) | 4,207.61 mi (6,771.49 km) |
| Newcastle under Lyme to Orangeburg (South Carolina) | 3,961.99 mi (6,376.20 km) |
