| Newcastle under Lyme to Seymour (Tennessee) | 3,960.89 mi (6,374.43 km) |
| Newcastle under Lyme to Shady Hills (Florida) | 4,286.11 mi (6,897.83 km) |
| Newcastle under Lyme to Shafter (California) | 5,253.33 mi (8,454.42 km) |
| Newcastle under Lyme to Shaker Heights (Ohio) | 3,608.56 mi (5,807.42 km) |
| Newcastle under Lyme to Shakopee (Minnesota) | 3,897.48 mi (6,272.39 km) |
| Newcastle under Lyme to Sharon (Pennsylvania) | 3,578.80 mi (5,759.52 km) |
| Newcastle under Lyme to Sharonville (Ohio) | 3,821.75 mi (6,150.51 km) |
| Newcastle under Lyme to Shasta Lake (California) | 5,047.55 mi (8,123.25 km) |
| Newcastle under Lyme to Shawnee (Kansas) | 4,228.30 mi (6,804.80 km) |
| Newcastle under Lyme to Shawnee (Oklahoma) | 4,495.32 mi (7,234.52 km) |
| Newcastle under Lyme to Sheboygan (Wisconsin) | 3,738.18 mi (6,016.02 km) |
| Newcastle under Lyme to Shelby (North Carolina) | 3,901.15 mi (6,278.29 km) |
| Newcastle under Lyme to Shelbyville (Indiana) | 3,862.69 mi (6,216.40 km) |
| Newcastle under Lyme to Shelbyville (Kentucky) | 3,905.22 mi (6,284.84 km) |
| Newcastle under Lyme to Shelbyville (Tennessee) | 4,085.36 mi (6,574.76 km) |
