| Newcastle under Lyme to Southern Pines (North Carolina) | 3,819.92 mi (6,147.56 km) |
| Newcastle under Lyme to Southfield (Michigan) | 3,628.43 mi (5,839.39 km) |
| Newcastle under Lyme to Southgate (Michigan) | 3,638.79 mi (5,856.07 km) |
| Newcastle under Lyme to Southlake (Texas) | 4,627.33 mi (7,446.97 km) |
| Newcastle under Lyme to Spanaway (Washington) | 4,679.14 mi (7,530.35 km) |
| Newcastle under Lyme to Spanish Fork (Utah) | 4,753.47 mi (7,649.98 km) |
| Newcastle under Lyme to Spanish Lake (Missouri) | 4,067.88 mi (6,546.61 km) |
| Newcastle under Lyme to Spanish Springs (Nevada) | 5,027.60 mi (8,091.14 km) |
| Newcastle under Lyme to Sparks (Nevada) | 5,033.76 mi (8,101.05 km) |
| Newcastle under Lyme to Spartanburg (South Carolina) | 3,933.25 mi (6,329.95 km) |
| Newcastle under Lyme to Spearfish (South Dakota) | 4,265.49 mi (6,864.64 km) |
| Newcastle under Lyme to Speedway (Indiana) | 3,868.33 mi (6,225.48 km) |
| Newcastle under Lyme to Spencer (Iowa) | 4,035.74 mi (6,494.90 km) |
| Newcastle under Lyme to Spokane (Washington) | 4,511.56 mi (7,260.66 km) |
| Newcastle under Lyme to Spokane Valley (Washington) | 4,506.27 mi (7,252.14 km) |
