| Newcastle under Lyme to St. Simons (Georgia) | 4,098.19 mi (6,595.40 km) |
| Newcastle under Lyme to Stafford (Texas) | 4,741.76 mi (7,631.13 km) |
| Newcastle under Lyme to Stallings (North Carolina) | 3,874.51 mi (6,235.41 km) |
| Newcastle under Lyme to Stamford (Connecticut) | 3,310.54 mi (5,327.81 km) |
| Newcastle under Lyme to Stanford (California) | 5,230.55 mi (8,417.76 km) |
| Newcastle under Lyme to Stanton (California) | 5,311.81 mi (8,548.54 km) |
| Newcastle under Lyme to Star (Idaho) | 4,704.66 mi (7,571.42 km) |
| Newcastle under Lyme to Starkville (Mississippi) | 4,280.72 mi (6,889.15 km) |
| Newcastle under Lyme to State College (Pennsylvania) | 3,495.34 mi (5,625.20 km) |
| Newcastle under Lyme to Staten Island (New York) | 3,357.34 mi (5,403.11 km) |
| Newcastle under Lyme to Statesboro (Georgia) | 4,050.96 mi (6,519.39 km) |
| Newcastle under Lyme to Statesville (North Carolina) | 3,850.22 mi (6,196.33 km) |
| Newcastle under Lyme to Staunton (Virginia) | 3,664.65 mi (5,897.68 km) |
| Newcastle under Lyme to Steamboat Springs (Colorado) | 4,575.58 mi (7,363.68 km) |
| Newcastle under Lyme to Steiner Ranch (Texas) | 4,792.27 mi (7,712.41 km) |
