| Niles to Enterprise (Nevada) | 1,522.09 mi (2,449.56 km) |
| Niles to Enumclaw (Washington) | 1,704.26 mi (2,742.74 km) |
| Niles to Ephrata (Pennsylvania) | 618.20 mi (994.89 km) |
| Niles to Erie (Colorado) | 906.84 mi (1,459.42 km) |
| Niles to Erie (Pennsylvania) | 396.71 mi (638.44 km) |
| Niles to Erlanger (Kentucky) | 268.50 mi (432.11 km) |
| Niles to Escanaba (Michigan) | 259.50 mi (417.63 km) |
| Niles to Escondido (California) | 1,705.72 mi (2,745.08 km) |
| Niles to Española (New Mexico) | 1,062.12 mi (1,709.32 km) |
| Niles to Essex (Maryland) | 624.13 mi (1,004.44 km) |
| Niles to Essex Junction (Vermont) | 757.65 mi (1,219.32 km) |
| Niles to Estelle (Louisiana) | 851.39 mi (1,370.18 km) |
| Niles to Estero (Florida) | 1,130.52 mi (1,819.40 km) |
| Niles to Euclid (Ohio) | 325.32 mi (523.56 km) |
| Niles to Eufaula (Alabama) | 714.20 mi (1,149.39 km) |
