| Opelika to Des Plaines (Illinois) | 662.21 mi (1,065.73 km) |
| Opelika to Desert Hot Springs (California) | 1,794.94 mi (2,888.68 km) |
| Opelika to DeSoto (Texas) | 668.06 mi (1,075.14 km) |
| Opelika to Destin (Florida) | 169.30 mi (272.46 km) |
| Opelika to Destrehan (Louisiana) | 348.58 mi (560.98 km) |
| Opelika to Detroit (Michigan) | 683.13 mi (1,099.39 km) |
| Opelika to Diamond Bar (California) | 1,867.15 mi (3,004.89 km) |
| Opelika to Diamond Springs (California) | 2,020.36 mi (3,251.45 km) |
| Opelika to Dickinson (North Dakota) | 1,343.76 mi (2,162.58 km) |
| Opelika to Dickinson (Texas) | 614.08 mi (988.27 km) |
| Opelika to Dickson (Tennessee) | 261.03 mi (420.08 km) |
| Opelika to Difficult Run (Virginia) | 622.78 mi (1,002.27 km) |
| Opelika to Dinuba (California) | 1,943.19 mi (3,127.26 km) |
| Opelika to Discovery Bay (California) | 2,061.62 mi (3,317.86 km) |
| Opelika to Dix Hills (New York) | 870.83 mi (1,401.46 km) |
