| Opelika to Effingham (Illinois) | 480.27 mi (772.91 km) |
| Opelika to Eggertsville (New York) | 796.60 mi (1,282.01 km) |
| Opelika to Egypt Lake-Leto (Florida) | 363.60 mi (585.16 km) |
| Opelika to El Cajon (California) | 1,828.79 mi (2,943.16 km) |
| Opelika to El Campo (Texas) | 688.17 mi (1,107.50 km) |
| Opelika to El Centro (California) | 1,748.41 mi (2,813.80 km) |
| Opelika to El Cerrito (California) | 2,099.94 mi (3,379.53 km) |
| Opelika to El Dorado (Arkansas) | 424.21 mi (682.70 km) |
| Opelika to El Dorado (Kansas) | 738.86 mi (1,189.08 km) |
| Opelika to El Dorado Hills (California) | 2,031.66 mi (3,269.64 km) |
| Opelika to El Mirage (Arizona) | 1,556.37 mi (2,504.73 km) |
| Opelika to El Monte (California) | 1,878.71 mi (3,023.48 km) |
| Opelika to El Paso (Texas) | 1,229.43 mi (1,978.58 km) |
| Opelika to El Paso de Robles (California) | 2,016.92 mi (3,245.92 km) |
| Opelika to El Reno (Oklahoma) | 746.65 mi (1,201.61 km) |
