| Opelika to Elyria (Ohio) | 628.45 mi (1,011.40 km) |
| Opelika to Emeryville (California) | 2,099.58 mi (3,378.94 km) |
| Opelika to Emmaus (Pennsylvania) | 771.21 mi (1,241.14 km) |
| Opelika to Emporia (Kansas) | 725.32 mi (1,167.30 km) |
| Opelika to Encinitas (California) | 1,843.61 mi (2,967.00 km) |
| Opelika to Endicott (New York) | 827.49 mi (1,331.71 km) |
| Opelika to Endwell (New York) | 829.96 mi (1,335.70 km) |
| Opelika to Englewood (Colorado) | 1,192.79 mi (1,919.60 km) |
| Opelika to Englewood (Florida) | 432.84 mi (696.59 km) |
| Opelika to Englewood (New Jersey) | 848.14 mi (1,364.95 km) |
| Opelika to Englewood (Ohio) | 501.23 mi (806.65 km) |
| Opelika to Enid (Oklahoma) | 755.99 mi (1,216.65 km) |
| Opelika to Ennis (Texas) | 656.17 mi (1,056.01 km) |
| Opelika to Ensley (Florida) | 184.99 mi (297.71 km) |
| Opelika to Enterprise (Alabama) | 96.17 mi (154.77 km) |
