| Opelika to Enterprise (Nevada) | 1,711.99 mi (2,755.18 km) |
| Opelika to Enumclaw (Washington) | 2,157.67 mi (3,472.43 km) |
| Opelika to Ephrata (Pennsylvania) | 728.12 mi (1,171.79 km) |
| Opelika to Erie (Colorado) | 1,203.63 mi (1,937.06 km) |
| Opelika to Erie (Pennsylvania) | 714.87 mi (1,150.46 km) |
| Opelika to Erlanger (Kentucky) | 440.94 mi (709.63 km) |
| Opelika to Escanaba (Michigan) | 908.77 mi (1,462.52 km) |
| Opelika to Escondido (California) | 1,831.98 mi (2,948.28 km) |
| Opelika to Española (New Mexico) | 1,200.55 mi (1,932.09 km) |
| Opelika to Essex (Maryland) | 677.52 mi (1,090.36 km) |
| Opelika to Essex Junction (Vermont) | 1,049.55 mi (1,689.08 km) |
| Opelika to Estelle (Louisiana) | 340.18 mi (547.47 km) |
| Opelika to Estero (Florida) | 481.42 mi (774.77 km) |
| Opelika to Euclid (Ohio) | 652.33 mi (1,049.82 km) |
| Opelika to Eufaula (Alabama) | 53.55 mi (86.18 km) |
