| Opelika to Olympia (Washington) | 2,196.39 mi (3,534.74 km) |
| Opelika to Olympia Heights (Florida) | 567.32 mi (913.02 km) |
| Opelika to Omaha (Nebraska) | 835.74 mi (1,345.00 km) |
| Opelika to On Top of the World Designated Place (Florida) | 306.43 mi (493.15 km) |
| Opelika to Onalaska (Wisconsin) | 837.14 mi (1,347.25 km) |
| Opelika to Oneida (New York) | 892.32 mi (1,436.05 km) |
| Opelika to Oneonta (New York) | 879.97 mi (1,416.17 km) |
| Opelika to Ontario (California) | 1,854.91 mi (2,985.19 km) |
| Opelika to Ontario (Oregon) | 1,868.68 mi (3,007.35 km) |
| Opelika to Opa-locka (Florida) | 559.73 mi (900.80 km) |
| Opelika to Opelousas (Louisiana) | 421.18 mi (677.83 km) |
| Opelika to Orange (California) | 1,869.01 mi (3,007.88 km) |
| Opelika to Orange (Texas) | 524.47 mi (844.05 km) |
| Opelika to Orange City (Florida) | 353.74 mi (569.28 km) |
| Opelika to Orangeburg (South Carolina) | 267.32 mi (430.21 km) |
