| Opelika to Oswego (Illinois) | 644.21 mi (1,036.75 km) |
| Opelika to Oswego (New York) | 887.08 mi (1,427.61 km) |
| Opelika to Otsego (Minnesota) | 975.76 mi (1,570.34 km) |
| Opelika to Ottawa (Illinois) | 629.99 mi (1,013.87 km) |
| Opelika to Ottawa (Kansas) | 689.68 mi (1,109.93 km) |
| Opelika to Ottumwa (Iowa) | 695.94 mi (1,120.01 km) |
| Opelika to Overland (Missouri) | 502.18 mi (808.19 km) |
| Opelika to Overland Park (Kansas) | 675.67 mi (1,087.38 km) |
| Opelika to Overlea (Maryland) | 677.32 mi (1,090.04 km) |
| Opelika to Oviedo (Florida) | 372.09 mi (598.83 km) |
| Opelika to Owasso (Oklahoma) | 645.57 mi (1,038.94 km) |
| Opelika to Owatonna (Minnesota) | 896.01 mi (1,441.99 km) |
| Opelika to Owensboro (Kentucky) | 365.55 mi (588.29 km) |
| Opelika to Owings Mills (Maryland) | 668.43 mi (1,075.73 km) |
| Opelika to Owosso (Michigan) | 717.01 mi (1,153.92 km) |
