| Opelika to Santa Rosa (California) | 2,121.23 mi (3,413.78 km) |
| Opelika to Santaquin (Utah) | 1,548.16 mi (2,491.52 km) |
| Opelika to Santee (California) | 1,829.67 mi (2,944.57 km) |
| Opelika to Sapulpa (Oklahoma) | 653.62 mi (1,051.90 km) |
| Opelika to Saraland (Alabama) | 203.21 mi (327.03 km) |
| Opelika to Sarasota (Florida) | 404.90 mi (651.63 km) |
| Opelika to Sarasota Springs (Florida) | 408.52 mi (657.45 km) |
| Opelika to Saratoga (California) | 2,086.28 mi (3,357.55 km) |
| Opelika to Saratoga Springs (New York) | 955.86 mi (1,538.30 km) |
| Opelika to Saratoga Springs (Utah) | 1,559.41 mi (2,509.63 km) |
| Opelika to Sartell (Minnesota) | 1,011.48 mi (1,627.82 km) |
| Opelika to Satellite Beach (Florida) | 420.46 mi (676.67 km) |
| Opelika to Sauk Rapids (Minnesota) | 1,008.60 mi (1,623.19 km) |
| Opelika to Sault Ste. Marie (Michigan) | 956.38 mi (1,539.14 km) |
| Opelika to Savage (Minnesota) | 938.85 mi (1,510.94 km) |
