| Opelika to Savannah (Georgia) | 248.72 mi (400.27 km) |
| Opelika to Sayreville (New Jersey) | 815.52 mi (1,312.46 km) |
| Opelika to Sayville (New York) | 879.31 mi (1,415.11 km) |
| Opelika to Scaggsville (Maryland) | 652.41 mi (1,049.95 km) |
| Opelika to Scarsdale (New York) | 860.40 mi (1,384.68 km) |
| Opelika to Schaumburg (Illinois) | 664.13 mi (1,068.81 km) |
| Opelika to Schenectady (New York) | 937.58 mi (1,508.89 km) |
| Opelika to Schererville (Indiana) | 620.24 mi (998.19 km) |
| Opelika to Schertz (Texas) | 790.57 mi (1,272.31 km) |
| Opelika to Schiller Park (Illinois) | 656.74 mi (1,056.92 km) |
| Opelika to Schofield Barracks (Hawaii) | 4,454.92 mi (7,169.50 km) |
| Opelika to Scotchtown (New York) | 858.50 mi (1,381.63 km) |
| Opelika to Scottdale (Georgia) | 101.38 mi (163.16 km) |
| Opelika to Scotts Valley (California) | 2,086.13 mi (3,357.30 km) |
| Opelika to Scottsbluff (Nebraska) | 1,185.94 mi (1,908.59 km) |
