| Opelika to Scottsboro (Alabama) | 142.33 mi (229.06 km) |
| Opelika to Scottsdale (Arizona) | 1,529.32 mi (2,461.20 km) |
| Opelika to Scranton (Pennsylvania) | 806.30 mi (1,297.62 km) |
| Opelika to Seabrook (Maryland) | 646.59 mi (1,040.59 km) |
| Opelika to Seabrook (Texas) | 608.84 mi (979.83 km) |
| Opelika to Seaford (New York) | 858.75 mi (1,382.03 km) |
| Opelika to Seagoville (Texas) | 649.39 mi (1,045.09 km) |
| Opelika to Seal Beach (California) | 1,883.65 mi (3,031.44 km) |
| Opelika to Searcy (Arkansas) | 405.58 mi (652.71 km) |
| Opelika to Seaside (California) | 2,077.10 mi (3,342.77 km) |
| Opelika to SeaTac (Washington) | 2,175.86 mi (3,501.71 km) |
| Opelika to Seattle (Washington) | 2,180.11 mi (3,508.55 km) |
| Opelika to Sebastian (Florida) | 446.02 mi (717.79 km) |
| Opelika to Sebring (Florida) | 428.10 mi (688.97 km) |
| Opelika to Secaucus (New Jersey) | 839.61 mi (1,351.22 km) |
