| Opelika to Security-Widefield (Colorado) | 1,160.76 mi (1,868.06 km) |
| Opelika to Sedalia (Missouri) | 606.88 mi (976.68 km) |
| Opelika to Sedro-Woolley (Washington) | 2,192.44 mi (3,528.39 km) |
| Opelika to Seguin (Texas) | 773.79 mi (1,245.30 km) |
| Opelika to Selden (New York) | 885.88 mi (1,425.69 km) |
| Opelika to Selma (Alabama) | 97.97 mi (157.66 km) |
| Opelika to Selma (California) | 1,955.08 mi (3,146.39 km) |
| Opelika to Selma (Texas) | 793.49 mi (1,276.99 km) |
| Opelika to Seminole (Florida) | 367.05 mi (590.70 km) |
| Opelika to Seven Hills (Ohio) | 635.95 mi (1,023.47 km) |
| Opelika to Seven Oaks (South Carolina) | 262.40 mi (422.29 km) |
| Opelika to Severn (Maryland) | 659.84 mi (1,061.91 km) |
| Opelika to Severna Park (Maryland) | 662.94 mi (1,066.90 km) |
| Opelika to Sevierville (Tennessee) | 245.65 mi (395.34 km) |
| Opelika to Seymour (Indiana) | 435.30 mi (700.55 km) |
