| Opelika to Seymour (Tennessee) | 240.53 mi (387.09 km) |
| Opelika to Shady Hills (Florida) | 338.90 mi (545.40 km) |
| Opelika to Shafter (California) | 1,936.21 mi (3,116.03 km) |
| Opelika to Shaker Heights (Ohio) | 644.27 mi (1,036.84 km) |
| Opelika to Shakopee (Minnesota) | 942.85 mi (1,517.37 km) |
| Opelika to Sharon (Pennsylvania) | 650.38 mi (1,046.68 km) |
| Opelika to Sharonville (Ohio) | 460.68 mi (741.39 km) |
| Opelika to Shasta Lake (California) | 2,107.12 mi (3,391.08 km) |
| Opelika to Shawnee (Kansas) | 686.19 mi (1,104.31 km) |
| Opelika to Shawnee (Oklahoma) | 688.79 mi (1,108.50 km) |
| Opelika to Sheboygan (Wisconsin) | 776.00 mi (1,248.85 km) |
| Opelika to Shelby (North Carolina) | 284.92 mi (458.53 km) |
| Opelika to Shelbyville (Indiana) | 475.48 mi (765.21 km) |
| Opelika to Shelbyville (Kentucky) | 383.25 mi (616.78 km) |
| Opelika to Shelbyville (Tennessee) | 205.47 mi (330.67 km) |
