| Opelika to Silver Firs (Washington) | 2,176.62 mi (3,502.93 km) |
| Opelika to Silver Spring (Maryland) | 640.61 mi (1,030.96 km) |
| Opelika to Silver Springs Shores (Florida) | 315.95 mi (508.48 km) |
| Opelika to Silverdale (Washington) | 2,197.04 mi (3,535.80 km) |
| Opelika to Silverton (Oregon) | 2,162.40 mi (3,480.05 km) |
| Opelika to Simi Valley (California) | 1,918.18 mi (3,087.01 km) |
| Opelika to Simpsonville (South Carolina) | 229.27 mi (368.97 km) |
| Opelika to Sioux City (Iowa) | 906.93 mi (1,459.56 km) |
| Opelika to Sioux Falls (South Dakota) | 970.73 mi (1,562.24 km) |
| Opelika to Skokie (Illinois) | 660.53 mi (1,063.03 km) |
| Opelika to Sleepy Hollow (New York) | 860.99 mi (1,385.63 km) |
| Opelika to Slidell (Louisiana) | 307.00 mi (494.07 km) |
| Opelika to Smithfield (North Carolina) | 447.65 mi (720.43 km) |
| Opelika to Smithfield (Utah) | 1,578.50 mi (2,540.35 km) |
| Opelika to Smithville (Missouri) | 692.42 mi (1,114.34 km) |
