| Opelika to Southern Pines (North Carolina) | 384.42 mi (618.66 km) |
| Opelika to Southfield (Michigan) | 687.94 mi (1,107.13 km) |
| Opelika to Southgate (Michigan) | 670.00 mi (1,078.26 km) |
| Opelika to Southlake (Texas) | 683.65 mi (1,100.24 km) |
| Opelika to Spanaway (Washington) | 2,175.67 mi (3,501.41 km) |
| Opelika to Spanish Fork (Utah) | 1,542.00 mi (2,481.62 km) |
| Opelika to Spanish Lake (Missouri) | 502.45 mi (808.61 km) |
| Opelika to Spanish Springs (Nevada) | 1,960.24 mi (3,154.70 km) |
| Opelika to Sparks (Nevada) | 1,962.39 mi (3,158.16 km) |
| Opelika to Spartanburg (South Carolina) | 253.26 mi (407.59 km) |
| Opelika to Spearfish (South Dakota) | 1,283.13 mi (2,064.99 km) |
| Opelika to Speedway (Indiana) | 495.19 mi (796.93 km) |
| Opelika to Spencer (Iowa) | 898.03 mi (1,445.24 km) |
| Opelika to Spokane (Washington) | 1,963.86 mi (3,160.52 km) |
| Opelika to Spokane Valley (Washington) | 1,955.09 mi (3,146.41 km) |
