| Opelika to St. Simons (Georgia) | 255.51 mi (411.20 km) |
| Opelika to Stafford (Texas) | 637.58 mi (1,026.09 km) |
| Opelika to Stallings (North Carolina) | 319.01 mi (513.39 km) |
| Opelika to Stamford (Connecticut) | 874.22 mi (1,406.92 km) |
| Opelika to Stanford (California) | 2,093.60 mi (3,369.33 km) |
| Opelika to Stanton (California) | 1,878.83 mi (3,023.68 km) |
| Opelika to Star (Idaho) | 1,839.86 mi (2,960.97 km) |
| Opelika to Starkville (Mississippi) | 207.42 mi (333.81 km) |
| Opelika to State College (Pennsylvania) | 698.63 mi (1,124.34 km) |
| Opelika to Staten Island (New York) | 827.74 mi (1,332.11 km) |
| Opelika to Statesboro (Georgia) | 210.33 mi (338.49 km) |
| Opelika to Statesville (North Carolina) | 335.81 mi (540.43 km) |
| Opelika to Staunton (Virginia) | 520.11 mi (837.04 km) |
| Opelika to Steamboat Springs (Colorado) | 1,302.45 mi (2,096.08 km) |
| Opelika to Steiner Ranch (Texas) | 753.79 mi (1,213.11 km) |
