| Opelika to Storm Lake (Iowa) | 872.86 mi (1,404.73 km) |
| Opelika to Storrs (Connecticut) | 957.54 mi (1,541.01 km) |
| Opelika to Stoughton (Wisconsin) | 739.28 mi (1,189.75 km) |
| Opelika to Stow (Ohio) | 627.17 mi (1,009.33 km) |
| Opelika to Streamwood (Illinois) | 664.63 mi (1,069.63 km) |
| Opelika to Streator (Illinois) | 614.95 mi (989.66 km) |
| Opelika to Streetsboro (Ohio) | 632.93 mi (1,018.60 km) |
| Opelika to Strongsville (Ohio) | 628.82 mi (1,011.99 km) |
| Opelika to Stuart (Florida) | 486.71 mi (783.29 km) |
| Opelika to Stuarts Draft (Virginia) | 514.30 mi (827.68 km) |
| Opelika to Sturgis (Michigan) | 631.37 mi (1,016.09 km) |
| Opelika to Suamico (Wisconsin) | 839.85 mi (1,351.61 km) |
| Opelika to Sudley (Virginia) | 611.57 mi (984.23 km) |
| Opelika to Suffern (New York) | 851.00 mi (1,369.55 km) |
| Opelika to Suffolk (Virginia) | 568.98 mi (915.68 km) |
