| Opelika to University Place (Washington) | 2,183.21 mi (3,513.53 km) |
| Opelika to Upland (California) | 1,857.41 mi (2,989.21 km) |
| Opelika to Upper Arlington (Ohio) | 524.82 mi (844.62 km) |
| Opelika to Upper Grand Lagoon (Florida) | 173.52 mi (279.26 km) |
| Opelika to Upper Montclair (New Jersey) | 836.80 mi (1,346.69 km) |
| Opelika to Urbana (Illinois) | 538.00 mi (865.83 km) |
| Opelika to Urbana (Maryland) | 642.79 mi (1,034.46 km) |
| Opelika to Urbana (Ohio) | 522.39 mi (840.70 km) |
| Opelika to Urbandale (Iowa) | 773.09 mi (1,244.16 km) |
| Opelika to Utica (New York) | 907.52 mi (1,460.51 km) |
| Opelika to Uvalde (Texas) | 885.22 mi (1,424.62 km) |
| Opelika to Vacaville (California) | 2,081.25 mi (3,349.45 km) |
| Opelika to Vadnais Heights (Minnesota) | 950.26 mi (1,529.29 km) |
| Opelika to Vail (Arizona) | 1,475.03 mi (2,373.83 km) |
| Opelika to Valdosta (Georgia) | 175.64 mi (282.66 km) |
