| Orangeburg to Sacile | 4,749.11 mi (7,642.95 km) |
| Orangeburg to Sala Consilina | 5,069.66 mi (8,158.83 km) |
| Orangeburg to Salemi | 5,027.90 mi (8,091.63 km) |
| Orangeburg to Salerno | 5,021.74 mi (8,081.71 km) |
| Orangeburg to Salo | 4,675.25 mi (7,524.09 km) |
| Orangeburg to Salsomaggiore Terme | 4,674.44 mi (7,522.78 km) |
| Orangeburg to Saluzzo | 4,568.61 mi (7,352.46 km) |
| Orangeburg to Salzano | 4,746.03 mi (7,638.00 km) |
| Orangeburg to Samarate | 4,598.19 mi (7,400.08 km) |
| Orangeburg to San Benedetto del Tronto | 4,906.14 mi (7,895.67 km) |
| Orangeburg to San Biagio di Callalta | 4,752.71 mi (7,648.75 km) |
| Orangeburg to San Bonifacio | 4,713.96 mi (7,586.38 km) |
| Orangeburg to San Casciano in Val di Pesa | 4,763.33 mi (7,665.83 km) |
| Orangeburg to San Cataldo | 5,095.54 mi (8,200.48 km) |
| Orangeburg to San Cesareo | 4,894.68 mi (7,877.22 km) |
