| Orangeburg to Savignano sul Rubicone | 4,803.38 mi (7,730.29 km) |
| Orangeburg to Savona | 4,622.70 mi (7,439.52 km) |
| Orangeburg to Scafati | 5,008.58 mi (8,060.53 km) |
| Orangeburg to Scalea | 5,099.10 mi (8,206.21 km) |
| Orangeburg to Scandiano | 4,712.43 mi (7,583.93 km) |
| Orangeburg to Scandicci | 4,760.46 mi (7,661.22 km) |
| Orangeburg to Schio | 4,707.63 mi (7,576.19 km) |
| Orangeburg to Sciacca | 5,052.12 mi (8,130.60 km) |
| Orangeburg to Scicli | 5,153.87 mi (8,294.35 km) |
| Orangeburg to Scordia | 5,143.01 mi (8,276.87 km) |
| Orangeburg to Scorze | 4,744.50 mi (7,635.54 km) |
| Orangeburg to Sedico | 4,727.32 mi (7,607.88 km) |
| Orangeburg to Sedriano | 4,610.11 mi (7,419.25 km) |
| Orangeburg to Segni | 4,908.88 mi (7,900.09 km) |
| Orangeburg to Segrate | 4,624.35 mi (7,442.18 km) |
