| Orangeburg to Spello | 4,850.88 mi (7,806.74 km) |
| Orangeburg to Spilamberto | 4,728.76 mi (7,610.21 km) |
| Orangeburg to Spilimbergo | 4,760.56 mi (7,661.39 km) |
| Orangeburg to Spinea | 4,749.18 mi (7,643.06 km) |
| Orangeburg to Spoleto | 4,858.97 mi (7,819.76 km) |
| Orangeburg to Spoltore | 4,933.96 mi (7,940.45 km) |
| Orangeburg to Spresiano | 4,744.05 mi (7,634.81 km) |
| Orangeburg to Squinzano | 5,179.19 mi (8,335.10 km) |
| Orangeburg to Statte | 5,136.22 mi (8,265.94 km) |
| Orangeburg to Stezzano | 4,635.31 mi (7,459.81 km) |
| Orangeburg to Strada | 4,771.46 mi (7,678.93 km) |
| Orangeburg to Stradella | 4,636.46 mi (7,461.66 km) |
| Orangeburg to Striano | 5,008.32 mi (8,060.11 km) |
| Orangeburg to Subiaco | 4,904.45 mi (7,892.95 km) |
| Orangeburg to Sulmona | 4,937.92 mi (7,946.82 km) |
