| Orangeburg to Ede | 4,298.65 mi (6,918.00 km) |
| Orangeburg to Eemnes | 4,277.37 mi (6,883.76 km) |
| Orangeburg to Eerbeek | 4,313.18 mi (6,941.39 km) |
| Orangeburg to Eersel | 4,300.97 mi (6,921.75 km) |
| Orangeburg to Eijsden | 4,330.57 mi (6,969.38 km) |
| Orangeburg to Eindhoven | 4,305.76 mi (6,929.45 km) |
| Orangeburg to Elburg | 4,296.60 mi (6,914.71 km) |
| Orangeburg to Emmeloord | 4,286.65 mi (6,898.70 km) |
| Orangeburg to Emmen | 4,330.12 mi (6,968.65 km) |
| Orangeburg to Enkhuizen | 4,269.07 mi (6,870.41 km) |
| Orangeburg to Enschede | 4,343.77 mi (6,990.63 km) |
| Orangeburg to Epe | 4,304.23 mi (6,926.99 km) |
| Orangeburg to Ermelo | 4,290.83 mi (6,905.42 km) |
| Orangeburg to Etten-Leur | 4,268.23 mi (6,869.06 km) |
| Orangeburg to Franeker | 4,266.90 mi (6,866.91 km) |
